Corneal cross-linking

Topic Status Complete

Epithelium-off corneal crosslinking to treat adults with keratoconus

Outcome of the appraisal


The evidence about epithelium-off corneal cross-linking (CXL) to treat adults with keratoconus is inconclusive. There is insufficient evidence to show that CXL is effective in the long term. HTW advises that routine provision is not currently supported. Research is recommended into the long term effectiveness and cost effectiveness of epithelium-off CXL in adults, compared with no treatment.

Why was this topic appraised?


This topic was proposed by Dr Kelechi Nnoaham, Director of Public Health, Cwm Taf University Health Board, and submitted to HTW by the Welsh Health Specialised Services Committee (WHSSC) to support evidence-informed decision making over provision of epithelium-off corneal crosslinking within NHS Wales.

Evidence Appraisal Review

EAR002 (02.2018)

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GUI002 (05.2018)

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