Fluorine- or gallium- prostate-specific membrane antigen positron emission tomography radiotracers
Topic Status Complete
Fluorine- or gallium- prostate-specific membrane antigen (PSMA) positron emission tomography (PET) radiotracers in the investigation of recurrent prostate cancer.
Outcome of the appraisal
The adoption of 68Ga prostate-specific membrane antigen (PSMA) positron emission tomography (PET) for the diagnosis of recurrent prostate cancer is partially supported by the evidence. The use of 68Ga PSMA PET provides a high degree of diagnostic accuracy on which to base management decisions as compared with conventional tracers. However, evidence comparing 68Ga PSMA PET to other tracers is limited, and estimating the cost of using 68Ga PSMA PET for the investigation of possible recurrent prostate cancer is complex and uncertain. Therefore, 68Ga PSMA PET is recommended if the service can be delivered at no greater cost than current standard care.
The adoption of 18F PSMA PET for the diagnosis of recurrent prostate cancer is not supported by the evidence.
Why was this topic appraised?
Many men who have been treated for prostate cancer may develop a recurrence of the cancer at a variable time after their initial treatment. This may be detected as a result of new symptoms or after biochemical surveillance. When this happens, early detection and precise localisation of the site of recurrence is critical so that appropriate further treatment decisions can be made. PSMA PET tracers have been developed to improve the accuracy of the diagnosis of recurrent prostate cancer.