Synovasure® Alpha Defensin Lateral Flow Test Kit

Topic Status Complete

Synovasure® Alpha Defensin Lateral Flow Test Kit for the assessment of periprosthetic joint infection.

Outcome of the appraisal

 

The use of Synovasure® alpha defensin testing shows promise in the diagnosis of peri-prosthetic hip and knee infection but the evidence does not currently support routine adoption. Synovasure® has the potential to further the diagnosis in patients with equivocal results from conventional testing but more convincing evidence is needed. HTW therefore recommends further research in this group of patients to define diagnostic accuracy, clinical outcomes and cost consequences of the use of synovasure® in addition to standard investigations.

Why was this topic appraised?

 

This topic was referred to HTW by the manufacturer of the Synovasure® alpha defensin test (Zimmer Biomet). Periprosthetic Joint Infection (PJI) is an uncommon but serious complication of hip and knee replacement surgery, affecting approximately 1% of hip arthroplasties and 1% to 2% of knee arthropIasties. PJI is difficult to diagnose and the use of the Synovasure® alpha defensin test may improve detection rates and ultimately result in more appropriate patient management.

Topic Exploration Report

TER015 (10.2018)

TER
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Evidence Appraisal Review

EAR008 (06.2019)

EAR
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Guidance


GUI008 (06.2019)

GUI
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