Coronavirus (COVID-19): Evidence digest

This digest contains links to pages on websites which collate or synthesize evidence relating to the COVID-19 pandemic.  This is a quick guide, and therefore not exhaustive, but it will be updated regularly as required.

Disclaimer: Inclusion below does not endorse content, but allows the user access to as much evidence on COVID-19 as possible.  Please follow the links for the latest advice from the UK & Welsh Governments, as well as Public Health Wales, WHSSC (Welsh Health Specialised Service Committee) & MHRA (Medicines & Healthcare products Regulatory Agency).

Click here to download the latest digest (PDF) or scroll down.

Last updated: 8 July 2020

Click on the bullet points below for a shortcut to the sections:

Update frequency

Wales

Section 1

1. Velindre University NHS Trust – COVID-19 Resources
Maintained by the Trust Library, searches are being conducted of key databases &
specific journals, as well as checking for society guidelines.
http://www.velindre-tr.wales.nhs.uk/covid-19-resources
Daily
2. NHS Wales e-library – Coronavirus COVID-19 Subject Guide for NHS Wales Health and Care Professionals
Many of the NHS Wales e-Library for Health e-resources have updated their systems to include information on coronavirus, COVID-19. This page contains links to information from publishers and suppliers, NHS Wales, Welsh Government and Royal Colleges and Societies to support health and care professionals in NHS Wales.
https://elh.nhs.wales/news1/latest-news/coronavirus-covid-19-subject-guide-for-nhs-wales-health-and-care-professionals/ 
Regularly (as and when new resources released)
3. Health and Care Research Wales – COVID-19 updates
https://www.healthandcareresearch.gov.wales/covid-19-updates/
Last update 12th  June 2020
4. North Wales Social Care and Well-being Services Improvement Collaborative – Latest information on Novel Coronavirus (COVID-19)
The Resources spreadsheet contains useful sources of information and guidance.
https://www.northwalescollaborative.wales/latest-information-on-novel-coronavirus-covid-19/
Last update 29th May 2020
5. Public Health Wales Observatory
http://www.publichealthwalesobservatory.wales.nhs.uk/eviidence-service-products
The Public Health Wales Observatory provides information and data to decision makers and the public on health issues.  The evidence and data are based on validated methods and robust quality control measures.  Follow the links below for your preferred language.
Healthcare staff mental wellbeing report – available in English & Welsh
Mental wellbeing in older people – available in English & Welsh
Last update 30th May 2020

 

Update frequency

Evidence Reviews

Section 2

6. Analytical Collaboration for COVID-19
Five organisations are collaborating to provide analytical support to the health and care system to help in the fight against COVID-19: the Health Foundation; King’s Fund; Nuffield Trust; and two specialist NHS analytical teams (Imperial College Health Partners and the Strategy Unit).  The five organisations are working in a coordinated way to provide analysis and expertise to support the NHS on COVID-19.
https://www.strategyunitwm.nhs.uk/covid19-and-coronavirus
Weekly (last alert 3rd July 2020)
7. CEBM (The Centre for Evidence-Based Medicine) – Oxford COVID-19 Evidence Service
The CEBM has committed its skills and expertise in evidence synthesis and dissemination to the effort against the current COVID-19 pandemic.  This page links to rapid reviews of primary care questions relating to the coronavirus pandemic.
https://www.cebm.net/oxford-covid-19-evidence-service/
Regularly (last update 6th July)
8. Cochrane Library
Overview page linking to Cochrane Reviews and related content from the Cochrane Library pertaining to the COVID-19 pandemic
https://www.cochranelibrary.com/covid-19 

Special Collections
**UPDATED** Coronavirus (COVID-19): evidence relevant to critical care
https://www.cochranelibrary.com/collections/doi/SC000039/full

**UPDATED** Coronavirus (COVID-19): infection control and prevention measures
https://www.cochranelibrary.com/collections/doi/SC000040/full

 

Coronavirus (COVID-19): effective options for quitting smoking during the pandemic
https://www.cochranelibrary.com/collections/doi/SC000042/full

 

Coronavirus (COVID-19): regional anaesthesia to reduce drug use in anaesthesia and avoid aerosol generation
https://www.cochranelibrary.com/collections/doi/SC000041/full

 

**UPDATED** Coronavirus (COVID-19): remote care through telehealth
https://www.cochranelibrary.com/collections/doi/SC000043/full

 

Coronavirus (COVID-19): optimizing health in the home workspace
https://www.cochranelibrary.com/collections/doi/SC000044/full

 

Rapid reviews
Video calls for reducing social isolation and loneliness in older people: a rapid review
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013632/full

 

Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a rapid review
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013600/full

 

Barriers and facilitators to healthcare workers’ adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013582/full

 

Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013597/full 

 

Quarantine alone or in combination with other public health measures to control COVID‐19: a rapid review
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013574/full

 

Cochrane review
**NEW** Antibody tests for identification of current and past infection with SARS‐CoV‐2
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013652/full

Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare staff
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011621.pub4/full

Regularly (last update 3rd July 2020)
 9. GOARN – COVID-19 Knowledge Hub
Curated by GOARN Partners including UN agencies, International and national NGOs, academic institutions and consortiums, the GOARN COVID-19 Information is a public platform for access to the best resources available to support your engagement in responding to this pandemic.
https://extranet.who.int/goarn/COVID19Hub 

Emerging COVID-19 evidence
Links to Curated COVID-19 publications & Rapid Evidence Reviews.
https://extranet.who.int/goarn/partner-resources/395  

 Not stated
 10. McMaster University – COVID-19 Rapid Evidence Reviews
COVID-END – COVID-19 Evidence Network to support Decision-making
The COVID-19 Evidence Network to support Decision-making (COVID-END) has come together to help those already supporting decision-making to find and use the best evidence and to help reduce duplication in and better coordinate the evidence syntheses, technology assessment and guidelines being produced.
https://www.mcmasterforum.org/networks/covid-end 

National Collaborating Centre for Methods and Tools
National Collaborating Centre for Methods and Tools has collected research questions for rapid evidence reviews currently in development.
https://www.nccmt.ca/knowledge-repositories/covid-19-evidence-reviews 

Last update:
Not stated

 

 

Not stated

11. **NEW** MaHTAS (Health Technology Assessment Section, Ministry of Health Malaysia) – COVID-19 Rapid Evidence Updates
There are four sections: screening & diagnosis; public health intervention; clinical management; and disinfection & sterilisation.
https://www.moh.gov.my/index.php/pages/view/2348

Last update 3rd July 2020

12. **NEW** Ministry of Health, Singapore – Clinical Evidence Summaries
Provides links to rapid evidence reviews related to COVID-19.
https://www.moh.gov.sg/covid-19/clinical-evidence-summaries

 

13. MRC Centre for Global Infectious Disease Analysis at Imperial College London – COVID-19
Provides links to all output from the Imperial College COVID-19 Response Team, including publicly published online reports, planning tools, scientific resources, publications and video updates.
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/

Last update 2nd July 2020

14. National University of Singapore Saw Swee Hock School of Public Health – Research on COVID-19
The Saw Swee Hock School of Public Health is collating the emerging evidence base and producing weekly COVID-19 Science Reports.
https://sph.nus.edu.sg/covid-19/research/

Last update 26th June 2020

15. NICE – Coronavirus (COVID-19)
NICE are producing a variety of different publications on COVID-19 and its effect on specific patient populations:

  • Rapid guidelines – 20 to date under the following headings
    • Managing symptoms and complications
    • Managing conditions that increase risk
    • Providing services during the pandemic
  • Rapid evidence summaries – 6 to date
    • **NEW** Vitamin D for COVID-19 – ES28
  • Medtech Innovation briefings – 3 to date
  • Clinical knowledge summaries – 5 to date

https://www.nice.org.uk/covid-19

Regularly

16. Usher Institute – UNCOVER (Usher Network for COVid-19 Evidence Reviews)
A network of population health researchers and information specialists who are committed to responding quickly to requests from policymakers for evidence reviews.  The completed rapid reviews are published on the website.
https://www.ed.ac.uk/usher/uncover

Last update 11th June 2020

Update frequency

Searchable Evidence ‘Hubs’/Databases

Section 3

17. Cochrane COVID-19 Study Register
The aim of the register is to support rapid evidence synthesis by all systematic review producers.  The register helps systematic reviewers prioritize topics, identify available evidence, and produce urgently needed reviews for front-line health professionals, public health policymakers, and research teams developing new therapeutic, diagnostic, and preventive interventions for COVID-19.
https://covid-19.cochrane.org/
Daily
18. COVID Evidence Database
COVID-evidence is a continuously updated database of the worldwide available evidence on interventions for COVID-19.  It provides information about worldwide planned, ongoing, and completed trials on any intervention to treat or prevent SARS-CoV-2-infections.  Combines automatic search strategies with expert manual extraction of key trial characteristics performed in duplicate.
https://covid-evidence.org/
Last update 23rd June 2020
19. COVID-19 Insights Platform
The COVID-19 Insights Platform is built from a Knowledge Graph containing a growing dataset of 52,000 Peer-Review and Pre-Print articles.
https://covid.deeperinsights.com/
Not stated
20. COVID-NMA – Living mapping and living systematic review of Covid-19 studies
A living mapping of ongoing research, followed by a living network meta-analysis (NMA) of study results as soon as they are available.
https://covid-nma.com/
Last update 6th July 2020
21. COVID-19 Open Research Dataset (CORD-19)
The Semantic Scholar team at the Allen Institute for AI has partnered with leading research groups to provide CORD-19, a free resource of more than 59,000 scholarly articles about the novel coronavirus for use by the global research community.
https://pages.semanticscholar.org/coronavirus-researchThe dataset is available in a public review on the Rayyan platform:
https://rayyan.qcri.org/reviews/125430
Daily
22.
EPPI-Centre – Living map of the evidence of studies on COVID-19 identified in MEDLINE and EMBASE, that groups the evidence into broad themes
A ‘map’ which allows you to access the evidence broken down into broad themes.  You can access the bibliographic records.
http://eppi.ioe.ac.uk/cms/Projects/DepartmentofHealthandSocialCare/Publishedreviews/COVID-19Livingsystematicmapoftheevidence/tabid/3765/Default.aspx
17 editions to date; last edition 29th June 2020
23. European Commission – COVID-19 In Vitro Diagnostic Devices and Test Methods Database
The objective of the JRC COVID-19 In Vitro Diagnostic Devices and Test Methods Database is to collect in a single place all publicly available information on performance of CE-marked in vitro diagnostic medical devices (IVDs) as well as in-house laboratory-developed devices, kits and related test methods for coronavirus SARS-CoV-2.
https://covid-19-diagnostics.jrc.ec.europa.eu/
Not stated
24. Evidence Aid – Coronavirus (COVID-19): Evidence Collection
Evidence Aid is preparing summaries of relevant research, which are available below in English with links to translations in other languages.  This collection includes summaries of systematic reviews that might be relevant to the direct impact of COVID-19 on health and other outcomes, the impact of the COVID-19 response on other conditions, and issues to consider for the recovery period after COVID-19.
https://www.evidenceaid.org/coronavirus-covid-19-evidence-collection/
Last update 7th July 2020
25. HESG (Health Economists’ Study Group) – COVID-19 Study Database
HESG has collated a database of studies relating to COVID-19.
https://hesg.org.uk/covid-19-study-database/
Not stated
26. Jonanna Briggs Institute – COVID-19 Special Collection
This provides health professionals and health organisations with free access to premier evidence-based point of care resources to inform and guide healthcare decision making with a focus on infection prevention and control measures, and mental health and well-being.
https://joannabriggs.org/ebp/covid-19
Not stated
27. LitCovid
LitCovid is a curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus.  It provides a central access to 2170 (and growing) relevant articles in PubMed.  The articles are further categorized by different research topics and geographic locations for improved access.
https://www.ncbi.nlm.nih.gov/research/coronavirus/
Daily
28. L·OVE – COVID-19
In order to respond to the COVID-19 emergency, the L·OVE platform has been adapted to include not only the existing systematic reviews but also other types of evidence synthesis (e.g. guidelines) and primary studies, published or ongoing, of any design.
https://app.iloveevidence.com/loves/5e6fdb9669c00e4ac072701d
Daily
29. McMaster University HiRU (Health Information Research Unit) – COVID-19 Evidence Alerts
This service alerts users to current best evidence for clinical care of people with threatened, suspected or confirmed COVID-19 infection. Reports are critically appraised for scientific merit, and those with acceptable scientific merit are appraised for relevance and importance by frontline clinicians.
https://plus.mcmaster.ca/COVID-19/
Last update 6th July 2020
30. metaEvidence – COVID-19
Live meta-analysis and evidence synthesis of potential therapies for COVID19.
http://metaevidence.org/COVID19.aspx
Not stated
31. NIHR (National Institute for Health Research) Innovation ObservatoryCOVID-19 Updates
This resource provides dashboards for Therapeutics, Diagnostics & Soft Intelligence in clinical development for COVID-19.
http://www.io.nihr.ac.uk/covid-19-updates/

 

**NEW** Learning for involvement – COVID-19 resources
COVID-19-specific resources to help you involve people in, or get involved in, research during the COVID-19 pandemic.
https://learningforinvolvement.org.uk/find-resource/?term=&date=DESC&region=undefined&resource_type=null&topic=covid-19#find-opportunity

Daily
32. NIPH (Norwegian Institute of Public Health) – Live map of COVID-19 evidence
A growing number of studies and reports are being published on COVID-19 and the pandemic.  This project will help decision makers and researchers navigate the research.  The main map gives an overview of all publications categorized according to publication type, population of interest and topic.  There are more detailed maps on

  • Etiology
  • Diagnosis
  • Infection prevention and control
  • Interventions to treat the infected patient
  • Interventions targeted at system level
  • Prognosis
  • Experiences and perception, social, political, economic aspects

https://www.fhi.no/en/qk/systematic-reviews-hta/map/

Updated 24th June 2020
33. VA Evidence Synthesis Program (ESP)
Catalogue of COVID-19 evidence reviews capturing the work of evidence synthesis groups in the US and around the world to maximise collective contributions to patients, frontline clinicians, researchers, and policymakers during the COVID-19 pandemic and avoid duplicating efforts.
http://covid19reviews.org/
Last update 4th July 2020
34. WebMD – COVID-19
A collection of breaking research from peer reviewed journals on COVID-19.  Free for all healthcare professionals to download the app (Read by QxMD) on their personal device, accessible using an NHS OpenAthens password.
https://qxmd.com/r/shared-collection/19211
Not stated
35. WHO Global research on coronavirus disease (COVID-19) database
Access to the latest scientific findings and knowledge on coronavirus disease (COVID-19) and compiled in a database.  The database can be downloaded into EndNote, should that be required.
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov
Daily

Update frequency

General resources

Section 4

36. American Medical Library Association – COVID-19 Resources for Medical Librarians & Other Health Information Professionals
This curated list has been created from crowd-sourced suggestions from MLA members and other health information professionals on the front lines of providing information during the COVID-19 pandemic. It is not intended to be an exhaustive list, as many librarians have already created excellent resource guides for their institutions and patients.
https://www.mlanet.org/p/cm/ld/fid=1712
Last update 8th May 2020 [no longer being updated]
37. British Medical Journal
BMJ Coronavirus (COVID-19) Hub
This page collects all BMJ coverage of the coronavirus outbreak from across the BMJ’s journals and learning resources. All articles and resources are freely available.
https://www.bmj.com/coronavirus 

BMJ Best Practice Coronavirus disease 2019 (COVID-19)
https://bestpractice.bmj.com/topics/en-gb/3000168

Regularly (last update 7th July 2020)
38. CDC (Centers for Disease Control and Prevention) – COVID-19 Research Articles Downloadable Database
The Stephen B. Thacker CDC Library is collecting COVID-19 (2019 Novel Coronavirus) research articles and compiling them into an easily accessible and downloadable database to help researchers find the latest COVID-19 research.
https://www.cdc.gov/library/researchguides/2019novelcoronavirus/researcharticles.html
Last update 6th July 2020
39. ECRI
ECRI has developed this resource centre to help hospitals, ambulatory care, and aging care facilities protect healthcare workers, residents, and patients.
https://www.ecri.org/coronavirus-covid-19-outbreak-preparedness-center
Last update 6th July 2020
40. EPPI-Centre – Resources relating to COVID-19
This list of resources was compiled by Melissa Harden, from the University of York, with input from other members of the NIHR Policy Research Programme Reviews Facility.
http://eppi.ioe.ac.uk/cms/Projects/DepartmentofHealthandSocialCare/Publishedreviews/COVID-19Livingsystematicmapoftheevidence/COVID-19Resources/tabid/3767/Default.aspx
Weekly
41. European Centre for Disease Prevention and Control
The COVID-19 pandemic is rapidly evolving, and outbreak investigations are ongoing.  ECDC is closely monitoring this outbreak, providing risk assessments, public health guidance, and advice on response activities to EU Member States and the EU Commission.
https://www.ecdc.europa.eu/en/covid-19-pandemic
Last update 7th July 2020
42. European Patients Forum – COVID-19 Resource Point
European Patients Forum will share credible figures, research articles and reports on COVID-19 and its effects on the patient and medical community here and in a weekly e-blast to our subscribers.
https://www.eu-patient.eu/COVID-19/covid-resource-point/
Last update 3rd July 2020
43. ISPM (Institute of Social and Preventive Medicine), University of Bern – Coronavirus Disease 2019 (COVID-19) Resources
The Institute of Social and Preventive Medicine at the University of Bern provides information and resources about the ongoing COVID-19 epidemic for scientists, public health experts, journalists and the public.
https://ispmbern.github.io/covid-19/SARS-CoV-2 references
https://zika.ispm.unibe.ch/assets/data/pub/ncov/
Last update 7th July 2020
44. ISQua (International Society For Quality In Health Care) – COVID-19 Information and Resources
Collated resources from around the world in order to help provide the most up to date information to the healthcare community. Contains links to webinars, articles, research papers, recordings, podcasts, and other research portals.
https://www.isqua.org/covid-19-research-page.html
Regularly
45. NHS CHAIN (Contact, Help, Advice and Information Network) – Covid-19
Potentially useful online resources suggested by CHAIN members.
https://www.chain-network.org.uk/resources.html
Last update 3rd June 2020
46. Public Health England – Finding the evidence: Coronavirus
PHE Knowledge and Library Services team (KLS) has produced this page to help those, working on the current coronavirus outbreak, to identify and access emerging evidence as it is published.
https://phelibrary.koha-ptfs.co.uk/coronavirusinformation/
Last update 18th June 2020
47. SCIE (Social Care Institute for Excellence) – Coronavirus (COVID-19) advice for social care
Advice for councils and care providers as the government works to delay the spread of COVID-19.
https://www.scie.org.uk/care-providers/coronavirus-covid-19
Last update 22nd June 2020

Health Technology Assessment (HTA) Organisations

This section lists other HTA organisations, as well as international HTA collaborations, and their response to COVID-19.

UK & Ireland

AWTTC – All Wales Therapeutics & Toxicology Centre
https://www.awttc.org/coronavirus-covid-19-therapeutic-advice
HIQA – Health Information & Quality Authority
https://www.hiqa.ie/reports-and-publications/all-publications?field_pub_published_year_target_id=All&keyspub=covid&=Apply
HIS – Healthcare Improvement Scotland
http://www.healthcareimprovementscotland.org/our_work/coronavirus_covid-19.aspx
NICE – National Institute for Health and Care Excellence
https://www.nice.org.uk/covid-19

International

CADTH – Canadian Agency for Drugs and Technologies in Health
https://covid.cadth.ca/
G-BA (Gemeinsamer Bundesausschuss) – Befristete Sonderregelungen im Zusammenhang mit der Coronavirus-Pandemie [in German]
https://www.g-ba.de/service/sonderregelungen-corona/
**NEW** IECS (Institute for Clinical Effectiveness and Health Policy), Argentina – COVID-19. Documentos de Evaluación de Tecnologías Sanitarias [in Spanish]
https://www.iecs.org.ar/covid/covid-ets/
**NEW** INESSS (Institut national d’excellence en santé et en services sociaux), Canada [in French]
https://www.inesss.qc.ca/covid-19.html

International Collaboration

**UPDATED** EUnetHTA – European Network for Health Technology Assessment
https://eunethta.eu/services/covid-19/
HTAi – Health Technology Assessment International
https://htai.org/blog/2020/04/02/how-can-we-help-hta-support-for-covid-19/
INAHTA – International Network of Agencies for Health Technology Assessment
http://www.inahta.org/covid-19-inahta-response/