Coronavirus (COVID-19): Evidence digest

This digest contains links to pages on websites which collate or synthesize evidence relating to the COVID-19 pandemic.  This is a quick guide, and therefore not exhaustive, but it will be updated regularly as required.

Disclaimer: Inclusion below does not endorse content, but allows the user access to as much evidence on COVID-19 as possible.  Please follow the links for the latest advice from the UK & Welsh Governments, as well as Public Health Wales, WHSSC (Welsh Health Specialised Service Committee) & MHRA (Medicines & Healthcare products Regulatory Agency).

Click here to download the latest digest (PDF) or scroll down.

Last updated: 24 March 2021

Click on the bullet points below for a shortcut to the sections:

Update frequency


Section 1

1. Velindre University NHS Trust – COVID-19 Resources
Maintained by the Trust Library, searches are being conducted of key databases &
specific journals, as well as checking for society guidelines.
2. NHS Wales e-library – Coronavirus COVID-19 Subject Guide for NHS Wales Health and Care Professionals
Many of the NHS Wales e-Library for Health e-resources have updated their systems to include information on coronavirus, COVID-19. This page contains links to information from publishers and suppliers, NHS Wales, Welsh Government and Royal Colleges and Societies to support health and care professionals in NHS Wales. 
Regularly (as and when new resources released)
3. Health and Care Research Wales – COVID-19 updates
Not stated
4. North Wales Social Care and Well-being Services Improvement Collaborative – Latest information on Novel Coronavirus (COVID-19)
The Resources spreadsheet contains useful sources of information and guidance.
Last update 11th March 2021
5. Public Health Wales Observatory
In support of the Health Protection team, the Evidence Service has developed a series of rapid summaries.


Rapid evidence summaries:

  • Models of mass vaccination in non-healthcare settings
  • Recruiting and training a skilled workforce to deliver mass vaccination
  • Communication to address concerns and encourage vaccine uptake
  • Managing expectations among groups not prioritised for early vaccination
  • Accessibility of mass vaccination
  • Digital systems to manage appointments and record vaccine administration in non-healthcare settings
  • Safe management of post vaccination recovery in non-health care settings



Other summaries:

  • Supporting the mental wellbeing of healthcare staff in times of crisis/pressure
  • Supporting wellbeing of older people when shielding/isolating
  • COVID-19 risk factors
Last update 15th December 2020


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Evidence Reviews

Section 2

6. Analytical Collaboration for COVID-19
Five organisations collaborated (March – December 2020) to provide analytical support to the health and care system to help in the fight against COVID-19: the Health Foundation; King’s Fund; Nuffield Trust; and two specialist NHS analytical teams (Imperial College Health Partners and the Strategy Unit).  These five organisations coordinated to provided analysis and expertise to support the NHS on COVID-19.
Last alert 2nd October 2020
7. CEBM (The Centre for Evidence-Based Medicine) – Oxford COVID-19 Evidence Service
The CEBM has committed its skills and expertise in evidence synthesis and dissemination to the effort against the current COVID-19 pandemic.  This page links to rapid reviews of primary care questions relating to the coronavirus pandemic.
Regularly (last update 16th March 2021)
8. Cochrane Library
Overview page linking to Cochrane Reviews and related content from the Cochrane Library pertaining to the COVID-19 pandemic


Special Collections
8 publications to date, the following have been updated recently:


Cochrane reviews
27 publications to date, the following has been recently published or updated:

Regularly (last update 15th March 2021)
 9. GOARN – COVID-19 Knowledge Hub
Curated by GOARN Partners including UN agencies, International and national NGOs, academic institutions and consortiums, the GOARN COVID-19 Information is a public platform for access to the best resources available to support your engagement in responding to this pandemic.


Emerging COVID-19 evidence
Links to Curated COVID-19 publications & Rapid Evidence Reviews.  

 Not stated
10. Healthcare Improvement Scotland – COVID-19: Evidence for Scotland
Healthcare Improvement Scotland are identifying reliable resources for NHS Scotland in the COVID-19 pandemic.  Includes a weekly update on the latest situation regarding COVID-19 and links to SIGN & Scottish Government Clinical Guidance Cell guidelines as well as rapid evidence reviews
 11. McMaster University – COVID-19 Rapid Evidence Reviews
COVID-END – COVID-19 Evidence Network to support Decision-making
The COVID-19 Evidence Network to support Decision-making (COVID-END) has come together to help those already supporting decision-making to find and use the best evidence and to help reduce duplication in and better coordinate the evidence syntheses, technology assessment and guidelines being produced.


National Collaborating Centre for Methods and Tools
National Collaborating Centre for Methods and Tools has collected research questions for rapid evidence reviews currently in development. 

Last update:
Not stated



Not stated

12. MaHTAS (Health Technology Assessment Section, Ministry of Health Malaysia) – COVID-19 Rapid Evidence Updates
There are four sections: screening & diagnosis; public health intervention; clinical management; and disinfection & sterilisation.

Last update 3rd July 2020

13. Ministry of Health, Singapore – Clinical Evidence Summaries
Provides links to rapid evidence reviews related to COVID-19.

Last update 26th August 2020

14. MRC Centre for Global Infectious Disease Analysis at Imperial College London – COVID-19
Provides links to all output from the Imperial College COVID-19 Response Team, including publicly published online reports, planning tools, scientific resources, publications and video updates.

Last update 31st December 2020

15. National University of Singapore Saw Swee Hock School of Public Health – Research on COVID-19
The Saw Swee Hock School of Public Health is collating the emerging evidence base.

Last update March 2021

16. NICE – Coronavirus (COVID-19)
NICE are producing a variety of different publications on COVID-19 and its effect on specific patient populations:

  • Rapid guidelines – 24 to date under the following headings
    • Managing symptoms and complications
    • Managing conditions that increase risk
    • Providing services during the pandemic
  • Rapid evidence summaries – 2 currently published
  • Medtech Innovation briefings – 6 to date


17. PCORI (Patient-Centered Outcomes Research Institute) – COVID-19 Health Care Horizon Scanning System
PCORI funds studies that can help patients and those who care for them make better-informed healthcare choices.

 Not stated

18. Usher Institute – UNCOVER (Usher Network for COVid-19 Evidence Reviews)
A network of population health researchers and information specialists who are committed to responding quickly to requests from policymakers for evidence reviews.  The completed rapid reviews are published on the website.

Last update 1st February 2021

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Searchable Evidence ‘Hubs’/Databases

Section 3

19. Cochrane COVID-19 Study Register
The aim of the register is to support rapid evidence synthesis by all systematic review producers.  The register helps systematic reviewers prioritize topics, identify available evidence, and produce urgently needed reviews for front-line health professionals, public health policymakers, and research teams developing new therapeutic, diagnostic, and preventive interventions for COVID-19.
20. COVID Evidence Database
COVID-evidence is a continuously updated database of the worldwide available evidence on interventions for COVID-19.  It provides information about worldwide planned, ongoing, and completed trials on any intervention to treat or prevent SARS-CoV-2-infections.  Combines automatic search strategies with expert manual extraction of key trial characteristics performed in duplicate.
Last update 15th March 2021
21. COVID-NMA – Living mapping and living systematic review of Covid-19 studies
A living mapping of ongoing research, followed by a living network meta-analysis (NMA) of study results as soon as they are available.
Last update 1st February 2021
22. COVID-19 Data Portal
The COVID-19 Data Portal brings together relevant datasets for sharing and analysis in an effort to accelerate coronavirus research. It enables researchers to upload, access and analyse COVID-19 related reference data and specialist datasets as part of the wider European COVID-19 Data Platform.
23. COVID-19 Open Research Dataset (CORD-19)
The Semantic Scholar team at the Allen Institute for AI has partnered with leading research groups to provide CORD-19, a free resource of more than 59,000 scholarly articles about the novel coronavirus for use by the global research community. dataset is available in a public review on the Rayyan platform:
EPPI-Centre – Living map of the evidence of studies on COVID-19 identified in MEDLINE and EMBASE, that groups the evidence into broad themes
A ‘map’ which allows you to access the evidence broken down into broad themes.  You can access the bibliographic records.
50 editions to date; last edition 1st March 2021
25. European Commission – COVID-19 In Vitro Diagnostic Devices and Test Methods Database
The objective of the JRC COVID-19 In Vitro Diagnostic Devices and Test Methods Database is to collect in a single place all publicly available information on performance of CE-marked in vitro diagnostic medical devices (IVDs) as well as in-house laboratory-developed devices, kits and related test methods for coronavirus SARS-CoV-2.
Not stated
26. Evidence Aid – Coronavirus (COVID-19): Evidence Collection
Evidence Aid is preparing summaries of relevant research, which are available below in English with links to translations in other languages.  This collection includes summaries of systematic reviews that might be relevant to the direct impact of COVID-19 on health and other outcomes, the impact of the COVID-19 response on other conditions, and issues to consider for the recovery period after COVID-19.
Last update 18th March 2021
27. HESG (Health Economists’ Study Group) – COVID-19 Study Database
HESG has collated a database of studies relating to COVID-19.
Not stated
28. LIVIVO – COVID-19 collection
Contains entries about COVID-19 / SARS-CoV-2 from various scientific sources as well as current relevant preprints from bioRxiv and medRxiv.
29. Jonanna Briggs Institute – COVID-19 Special Collection
This provides health professionals and health organisations with free access to premier evidence-based point of care resources to inform and guide healthcare decision making with a focus on infection prevention and control measures, and mental health and well-being.
Not stated
30. LitCovid
LitCovid is a curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus.  It provides a central access to 2170 (and growing) relevant articles in PubMed.  The articles are further categorized by different research topics and geographic locations for improved access.
31. L·OVE – COVID-19
In order to respond to the COVID-19 emergency, the L·OVE platform has been adapted to include not only the existing systematic reviews but also other types of evidence synthesis (e.g. guidelines) and primary studies, published or ongoing, of any design.
32. McMaster University HiRU (Health Information Research Unit) – COVID-19 Evidence Alerts
This service alerts users to current best evidence for clinical care of people with threatened, suspected or confirmed COVID-19 infection. Reports are critically appraised for scientific merit, and those with acceptable scientific merit are appraised for relevance and importance by frontline clinicians.
Last update 22nd March 2021
33. metaEvidence – COVID-19
Live meta-analysis and evidence synthesis of potential therapies for COVID19.
Not stated
34. NIHR (National Institute for Health Research) Innovation ObservatoryCOVID-19 Updates
This resource provides dashboards for Therapeutics, Diagnostics & Soft Intelligence in clinical development for COVID-19.


Learning for involvement – COVID-19 resources
COVID-19-specific resources to help you involve people in, or get involved in, research during the COVID-19 pandemic.


Last update 18th February 2021

35. NIPH (Norwegian Institute of Public Health) – Live map of COVID-19 evidence
A growing number of studies and reports are being published on COVID-19 and the pandemic.  This project will help decision makers and researchers navigate the research.  The main map gives an overview of all publications categorized according to publication type, population of interest and topic.  There are more detailed maps on

  • Etiology
  • Diagnosis
  • Infection prevention and control
  • Interventions to treat the infected patient
  • Prognosis
  • Experiences and perception, social, political, economic aspects

Last update 16th December 2020
36. VA Evidence Synthesis Program (ESP) – COVID-19 Evidence Reviews
Catalogue of COVID-19 evidence reviews capturing the work of evidence synthesis groups in the US and around the world to maximise collective contributions to patients, frontline clinicians, researchers, and policymakers during the COVID-19 pandemic and avoid duplicating efforts.
Last update 19th March 2021
37. WebMD – COVID-19
A collection of breaking research on COVID-19.
Not stated
38. WHO Global research on coronavirus disease (COVID-19) database
Access to the latest scientific findings and knowledge on coronavirus disease (COVID-19) and compiled in a database.  The database can be downloaded into EndNote, should that be required.

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General resources

Section 4

39. American Medical Library Association – COVID-19 Resources for Medical Librarians & Other Health Information Professionals
This curated list has been created from crowd-sourced suggestions from MLA members and other health information professionals on the front lines of providing information during the COVID-19 pandemic. It is not intended to be an exhaustive list, as many librarians have already created excellent resource guides for their institutions and patients.
Last update 8th May 2020 [no longer being updated]
40. British Medical Journal
BMJ Coronavirus (COVID-19) Hub
This page collects all BMJ coverage of the coronavirus outbreak from across the BMJ’s journals and learning resources. All articles and resources are freely available. 


BMJ Best Practice Coronavirus disease 2019 (COVID-19)

Regularly (last update 21st March 2021)
41. C19 Economics is a platform to enable, improve and share health economics evidence to inform COVID-related decision making and policies globally, with a focus on low and middle income countries (LMICs).
Not stated
42. **NEW** CADTH COVID-19 Grey Literature Resources
A Curated List of Evidence-Based Sources for Health Professionals, Librarians, and Researchers
Published 20th October 2020
43. CDC (Centers for Disease Control and Prevention) – COVID-19 Research Articles Downloadable Database
The Stephen B. Thacker CDC Library is collecting COVID-19 (2019 Novel Coronavirus) research articles and compiling them into an easily accessible and downloadable database to help researchers find the latest COVID-19 research.
Last update 9th October 2020
44. CONDOR (COVID-19 National DiagnOstic Research and Evaluation Platform
The CONDOR platform evaluates new COVID-19 diagnostics in the settings they will be used, such as in GP surgeries, care homes or hospitals, as well as their performance in laboratory settings.
Not stated
45. ECRI
ECRI has developed this resource centre to help hospitals, ambulatory care, and aging care facilities protect healthcare workers, residents, and patients.
Last update 19th March 2021
46. EPPI-Centre – Resources relating to COVID-19
The list of resources was put together during the planning stage of the COVID-19: a living systematic map of the evidence and has been updated as new resources have emerged.
Last update 15th March 2021
47. European Centre for Disease Prevention and Control
The COVID-19 pandemic is rapidly evolving, and outbreak investigations are ongoing.  ECDC is closely monitoring this outbreak, providing risk assessments, public health guidance, and advice on response activities to EU Member States and the EU Commission.
Last update 18th March 2021
48. European Patients Forum – COVID-19 Resource Point
European Patients Forum will share credible figures, research articles and reports on COVID-19 and its effects on the patient and medical community here and in a weekly e-blast to our subscribers.
49. **NEW** FIND – COVID-19 Test Directory & Pipeline
FIND have compiled a fully searchable directory that includes performance data (sensitivity and specificity) for antigen rapid diagnostic tests (Ag RDTs) and molecular point-of-care tests.
Not stated
50. ISPM (Institute of Social and Preventive Medicine), University of Bern – Coronavirus Disease 2019 (COVID-19) Resources
The Institute of Social and Preventive Medicine at the University of Bern provides information and resources about the ongoing COVID-19 epidemic for scientists, public health experts, journalists and the public. references
Last update 22nd March 2021
51. ISQua (International Society For Quality In Health Care) – COVID-19 Information and Resources
Collated resources from around the world in order to help provide the most up to date information to the healthcare community. Contains links to webinars, articles, research papers, recordings, podcasts, and other research portals.
50. NHS CHAIN (Contact, Help, Advice and Information Network) – Covid-19
Potentially useful online resources suggested by CHAIN members.
Last update 21st October 2020
52. Public Health England – Finding the evidence: Coronavirus
PHE Knowledge and Library Services team (KLS) has produced this page to help those, working on the current coronavirus outbreak, to identify and access emerging evidence as it is published.
Last update 1st March 2021
53. SCIE (Social Care Institute for Excellence) – Coronavirus (COVID-19) advice for social care
Advice for councils and care providers as the government works to delay the spread of COVID-19.
Last update December 2020

Health Technology Assessment (HTA) Organisations

This section lists other HTA organisations, as well as international HTA collaborations, and their response to COVID-19.

UK & Ireland

AWTTC – All Wales Therapeutics & Toxicology Centre
HIQA – Health Information & Quality Authority
HIS – Healthcare Improvement Scotland
NICE – National Institute for Health and Care Excellence
NIHR – National Institute for Health Research


CADTH – Canadian Agency for Drugs and Technologies in Health
G-BA (Gemeinsamer Bundesausschuss) – Befristete Sonderregelungen im Zusammenhang mit der Coronavirus-Pandemie [in German]
IECS (Institute for Clinical Effectiveness and Health Policy), Argentina – COVID-19. Documentos de Evaluación de Tecnologías Sanitarias [in Spanish]
INESSS (Institut national d’excellence en santé et en services sociaux), Canada [in French]

International Collaboration

EUnetHTA – European Network for Health Technology Assessment
HTAi – Health Technology Assessment International
INAHTA – International Network of Agencies for Health Technology Assessment